NC1101, a novel tetrahydropyrimidine-containing bleomycin analog from Streptomyces verticillus var. pingyangensis n. var.
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چکیده
منابع مشابه
Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003.
Bleomycin (BLM) biosynthesis has been studied as a model for hybrid peptide-polyketide natural product biosynthesis. Cloning, sequencing, and biochemical characterization of the blm biosynthetic gene cluster from Streptomyces verticillus ATCC15003 revealed that (1) the BLM hybrid peptide-polyketide aglycon is assembled by the BLM megasynthetase that consists of both nonribosomal peptide synthet...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2012
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2012.23